"Fascinating" - mr. spock
RESEARCH
RESEARCH
RESEARCH
RESEARCH
genome and epigenome editing
for nearly a decade, the lab has developed robust reagents and methods that enable targeted genome editing, including: zinc finger nucleases, tale nucleases, crispr/cas nucleases, and base editors.
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we have shown the utility of these platforms for targeted epigenome editing, through histone modification and heterotopic activation to alter gene expression.
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together, we and our collaborators have created genome and epigenome edits with high efficiencies in zebrafish, plants or human somatic and pluripotent stem cells.
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Keith's PRESENTATION at ASGCT 2023 summarizes the LAB's research achievements
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genome-wide assays: specificity
to understand the safety of genome editing technologies as potential therapeuties, we have developed assays such as guide-SEQ AND CIRCLE-SEQ THAT AIM TO DEFINE and detect OFF-TARGETS.
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as a lab
we continue to create novel cutting-edge technologies and explore high-throughput genome- and epigenome-editing capabilities
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we encourage interested undergraduate students, graduate students, and scientists from all backgrounds to inquire about opportunities to join our lab!!
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email: jounglab1@gmail.com
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See available plasmids at: https://www.addgene.org/Keith_Joung/
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